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Crystal structure of E. coli BAM in complex with darobactin
Antibiotics that target Gram-negative bacteria in new ways are needed to resolve the antimicrobial resistance crisis. Gram-negative bacteria are protected by an additional outer... -
Crystal structure of E. coli BAM in complex with dynobactin A
Discovery of antibiotics acting against Gram-negative species is uniquely challenging due to their restrictive penetration barrier. BamA, which inserts proteins into the outer... -
High-throughput screening of BAM inhibitors in native membrane environment
The outer membrane insertase of Gram-negative bacteria, BAM, is a key target for urgently needed novel antibiotics. Functional reconstitutions of BAM have so far been limited to...
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